1621 in science
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- Johann Schreck (1576–1630), also known as Johannes Schreck, Terrenz or Terrentius, introduces the telescope to China.
- The University of Oxford Botanic Garden, the oldest botanical garden in Great Britain, is founded as a physic garden by Henry Danvers, 1st Earl of Danby.
- A simple microscope is developed.
- Cornelius Vermuyden begins reclamation of Canvey Island in England.
- January 27 – Thomas Willis, English physician who contributes to knowledge of the nervous and cardiovascular systems (died 1675)
- July 2 – Thomas Harriot, English ethnographer, astronomer and mathematician (born c. 1560)
- September 1 – Bahāʾ al-dīn al-ʿĀmilī, Arab philosopher and astronomer (born 1547)
- Jan Jesenius, Slovak physician (born 1566)
- "Johannes Schreck-Terrentius Constantiensis: Wissenschaftler und Chinamissionar". HWTG Konstanz.
- "A History of The Gardens". The University of Oxford Botanic Garden. Archived from the original on 2011-07-09. Retrieved 2011-03-15.